Daptomycin susceptibility in enterococci isolated from urinary samples in a tertiary care hospital

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Original Article

Author Details : Saritha Yarava, Pradeep M.S.S*, Vishnuvardhan Rao K

Volume : 6, Issue : 1, Year : 2020

Article Page : 48-53

https://doi.org/10.18231/j.ijmmtd.2020.010

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Abstract

Introduction: Enterococci are gram positive cocci encountered in various human infections.The most
striking feature of enterococci is their relative and absolute resistance to variety of antibiotics.Vancomycin
resistant enterococci (VRE) were first described in late 1980 and the incidence of nosocomial infections
by VRE being 11.9% in Asia Pacific and 35.5% in U.S. Daptomycin is a lipopeptide antibiotic with
bactericidal activity .
Objective: To study the daptomycin susceptibility in enterococci isolated in urinary samples.
Results: A total of 76 strains of enterococci were isolated during the study period.25 (33%) were identified
as E.faecium and 51 (67%) as E.faecalis. Most of the Enterococcal isolates (82.8%) were resistant
to Norfloxacin followed by 71% being resistant to tetracycline and 76% of isolates were sensitive to
nitrofurantoin. Most of the E.faecium isolates were multidrug resistant. Of the 76 Enterococci isolated
only 2(2.63%) were VRE and both the VRE strains isolated were E.faecium. There was no resistance to
linezolid including the VRE strains. All the isolates 76 (100%) were sensitive to daptomycin including the
VRE strains.
Conclusions: Our study mainly focused on susceptibility of enterococcal isolates in urinary samples to
daptomycin which has bactericidal activity against gram positive organisms including multidrug resistant
strains. This study shows growing concern for increasing antibiotic resistance in enterococcal isolates and
treatment of these infections with daptomycin is invited as there are only few reports of daptomycin non
susceptible enterococci (DNSE).

Keywords: Enterocooci, Urinary tract infections, Drug resistance, VRE, Daptomycin.

How to cite : Yarava S, M.s.s P, Vishnuvardhan Rao K, Daptomycin susceptibility in enterococci isolated from urinary samples in a tertiary care hospital. IP Int J Med Microbiol Trop Dis 2020;6(1):48-53

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