Susceptibility analysis of various bacteria towards colistin and other antibiotics in clinical isolates

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Original Article

Author Details : Bhumireddy Rama Chandra Reddy, Ramavath Usha Rani, Sravanthi Brungi, Sreeja Vamsi Kogila*

Volume : 9, Issue : 4, Year : 2023

Article Page : 275-281

https://doi.org/10.18231/j.ijmmtd.2023.051

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Abstract

Objectives: This study aimed to determine the in vitro susceptibility of Gram-negative bacilli isolated from various clinical samples of patients admitted to ICUs of hospitals in Telangana region against colistin and compared with other antibiotics.
Materials and Methods: In the present study clinical pathogen isolates were used for the susceptibility test. A total of 1852 consecutive Gram-negative isolates were tested for Colistin susceptibility. All the bacterial isolates of Enterobacteriaceae (e.g., Escherichia coli, Klebsiella), Pseudomonas aeruginosa and Acineto bacterbaumanii were included. All Colistin resistant isolates were processed to detect the minimum inhibitory concentration (MIC) of antibiotics by the broth micro-dilution method.
Results: It was observed that in Pseudomonas spp. and E. colispp the susceptibility was quite significant whereas it was not much significant for other species of bacteria studied namely, Acinetobacter, Enterobacter, Klebsiella, and Proteus spp.
Conclusion: Pseudomonas spp. and E. coli resistance indicated that there is an argent need to get the current situation under control by implementing appropriate measures to slow down the progression of antibiotic resistance in gram-negative bacteria in Telangana.
Novelty: Pseudomonas and E. coli showed significant resistance to Colistin compared with other antibiotics than other gram-negative bacilli isolated from various clinical samples. There is a shortage of clinical data available in South India regarding the prevalence of colistin resistance. This study is one of the few studies that indicate the current scenario of resistance of gram-negative bacteria in this particular area.

Keywords: Colistin, Bacteria, Susceptibility, MIC, Clinical isolates

How to cite : Reddy B R C , Rani R U , Brungi S , Kogila S V , Susceptibility analysis of various bacteria towards colistin and other antibiotics in clinical isolates. IP Int J Med Microbiol Trop Dis 2023;9(4):275-281

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