Occurrence of nosocomial multi-drug resistant Klebsiella pneumoniae in India: A systemic review and meta-analysis

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Review Article

Author Details : Md. Mudassar Iqbal Lodhi*, Lakshminarayana S A, Aaftab G.P

Volume : 10, Issue : 1, Year : 2024

Article Page : 17-23

https://doi.org/10.18231/j.ijmmtd.2024.004

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Abstract

Introduction: The continuous rising of hospital acquired Multi Drug resistant Klebsiella pneumoniae creates an alarming condition in public health worldwide. Objective of this study is to identify quantitative analysis of hospital acquired Multi-Drug resistant Klebsiella pneumoniae in India. 
Materials and Methods: Data were collected from Pub Med and Google scholar specific study of India to identify prevalence of Multi-drug resistant nosocomial Klebsiella pneumoniae starting from 2011 to 2023. Literature review were collected and analysed through Preferred reporting Items for Systematic Reviews and meta-analysis (PRISMA) guideline and SPSS- 25 software used for Data analysis. Meta-analysis report reveals that prevalence of multi-drug resistant klebsiella pneumoniae among hospital acquired is 34.37 % and pooled prevalence rate of hospital acquired multi drug resistant klebsiella pneumoniae infection found
at 2 % (97.5 % CI, 2.5) with p-value is 0.01. Genotypic analysis reveals blaSHV gene identified most among the studied samples.
Conclusion: Prevalence of ESBL, MDR Klebsiella pneumoniae associated with nosocomial infections estimated and correlated with mortality and death ratio as well as antibiotic susceptibility tests pattern was analysed in India which shows continuous rising number of MDR and ESBL Klebsiella pneumoniae especially hospital acquired infection. A finding of this study is indicating alarming situation of public health and it should control through interdisciplinary one health approach.

Keywords: Klebsiella pneumoniae, Nosocomial Infections, Multi-Drug resistant (MDR), Extended spectrum β-lactamase (ESBL), Systematic & meta-analysis

How to cite : Lodhi M M I, Lakshminarayana S A, G.p A , Occurrence of nosocomial multi-drug resistant Klebsiella pneumoniae in India: A systemic review and meta-analysis. IP Int J Med Microbiol Trop Dis 2024;10(1):17-23

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