Inducible Clindamycin resistance and MRSA amongst Staphylococcus aureus isolates: A phenotypic detection

---

Original Article

Author Details : Tanvi Panwala, Purvi Gandhi*, Dipal Jethwa

Volume : 6, Issue : 4, Year : 2020

Article Page : 222-226

https://doi.org/10.18231/j.ijmmtd.2020.050

Suggest article by email

Get Permission

---

Abstract

Introduction: Now a days clinicians switch over to drug Clindamycin to treat Staphylococcus aureus infections. Clindamycin is belonging to lincosamide group. As frequent use of this Clindamycin develops resistance among patients and ultimately treatment failure.
Aim: This present research is done to identify type of resistance like inducible or constitutive macrolide lincosamide – streptogramin B (iMLSB /cMLSB) resistance and MS (Macrolide lincosamide streptogramin) phenotypes among Staphylococcus aureus isolated from various samples received in Microbiology laboratory of tertiary care hospital of south Gujarat.
Materials and Methods: Among various samples total 232 Staphylococcus aureus were isolated. And all these isolates were subjected to routine antibiotic sensitivity testing by kirbey bauer disc diffusion method. Methicillin resistance staphylococcus aureus (MRSA) detected by using Cefoxitin disc. D test is performed as per Clinical and laboratory standards institute (CLSI) guidelines on all isolates.
Results: Total of 232 Staphylococcus aureus were isolated, among them 109 were Methicillin sensitive Staphylococcus aureus (MSSA) and 123 were Methicillin resistant Staphylococcus aureus (MRSA). Prevalence of iMLSB, cMLSB and MS phenotype were 59.34% ,15.44% and 13% in MRSA while 12.84%, 14.67% and 22.93% respectively in MSSA.
Conclusion: This research helps to detect Clindamycin resistance among Staphylococcus aureus and role of D test before starting the treatment with Clindamycin. By these knowledge clinician can choose correct treatment and we can prevent a treatment failure.

Keywords: Saureus, Clindamycin, D test, MRSA, MSSA.

How to cite : Panwala T , Gandhi P , Jethwa D , Inducible Clindamycin resistance and MRSA amongst Staphylococcus aureus isolates: A phenotypic detection. IP Int J Med Microbiol Trop Dis 2020;6(4):222-226

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.