Helicobacter pylori: A key player in pathogenesis of Gastric Non-Hodgkin’s Lymphoma: A Case Report

Authors: trupti jansari, JAY JANSARI, VISHWA GEVARIYA, AMIT PRAVIN CHAUHAN, Shikha shah

DOI: 10.18231/j.ijmmtd.12628.1761393749

Keywords: stomach, helicobacter pylori, lymphoma, non – Hodgkin’s lymphoma, immunohistochemistry.

Abstract: Primary gastric lymphoma is one of the less common gastric malignancies as compared to adenocarcinoma. Numerous bacterial and viral infections are linked to their etiology. One of the most frequent associations is with helicobacter pylori infection that predisposes to the development of gastric lymphoma. Here we present a case of 48 years old Female with complains of nausea, vomiting, weight loss and epigastric pain since 2 months. Upper Gastrointestinal endoscopy showed ulcerative lesion involving pre pyloric region and lesser curvature. Patients have undergone surgery, and we received distal gastrectomy specimen in histopathology. The representative sections were given and stained with hematoxylin and eosin stain. Microscopy showed stomach walls infiltrated by small to medium sized atypical cells. Immunohistochemistry was positive for CD -45 and CD - 20 and negative for Synaptophysin and CK -7. The final diagnosis of Non – Hodgkin’s Lymphoma was given. This case highlights the association of helicobacter pylori with primary gastric lymphoma.