A distinctive genomic feature, the spike gene S Gene Target Failure (SGTF), enables accurate detection of the Alpha and Omicron SARS-CoV-2 variants of Gujarat region.

Authors: NILAY HARSHADKUMAR DAVE, Neeraj Arora, Dr Chetana Roat

Keywords: SARS-Cov-2, STGF, Spike Gene Target Failure, Alpha, Omicron, Taqpath RT-PCR, Next Generation Sequencing, VOC

SARS-COV-2 is the infectious agent that causes COVID-19. Several mutations in the spike gene are shared by the Alpha (B.1.1.7) and Omicron (B.1.1.529, BA.1, BA.4, and BA.5) variants of concern (VOC)....

Culture and Sensitivity in Cancer Patients Presenting with Sepsis

Authors: Veena Boswal, Anmol Mahani, Luckshay Sharma, Vipul Nautiyal, Viney Kumar, Mansi Barthwal

Keywords: Cancer, Sepsis, Antibiotic Resistance, Culture and Sensitivity, Bacteraemia, Chemotherapy, Retrospective Study

Introduction: Introduction: Cancer management has significantly evolved over recent decades with the advancement of multimodal treatment strategies, including surgery, chemotherapy, immunotherapy, and...

Study of Candida Infections in Hospitalized COVID-19 Patients: An Experience at a Dedicated COVID Hospital in Central India

Authors: Aniket Goenka, Saurabh G Agarwal, Sanyogita Jain, Kuldeep Singh, Rajdeep Paul, Ajay Goenka

Keywords: Candida species, COVID-19, antifungal resistance, fluconazole, Candida albicans, Candida tropicalis, diabetes, hypertension, tertiary care hospital

Background: Candida infections have become increasingly common in patients with COVID-19, particularly in those with comorbidities or requiring prolonged hospital stays. The growing incidence of funga...

Fairly Used Adult Male and Female Pants: Contributors of Methicillin-Resistant Staphylococcus aureus (MRSA) Spread in Abakaliki, Ebonyi State, Nigeria

Authors: Felicitas Ngozi Afiukwa, Victoria Obumneme Amaechi-Nnaji, Ruth Eberechukwu Anoh, Lynda Odinachi Nweke, AUSTINE OKPAGA UME

DOI: 10.18231/j.ijmmtd.11542.1761892222

Keywords: Male pants, Female pants, MRSA, Antibiotic resistance

Introduction: The importation and sale of second-hand clothing, commonly known as "Okrika," have become prevalent in Nigeria due to their affordability and accessibility. However, these garments often...

Phenotypic detection of β-lactamases producing Klebsiella pneumoniae and Acinetobacter baumannii isolated from the respiratory tract infections.

Authors: Shilpa Borehalli Mayegowda, Priyanka Lakshman, Sushma S Murthy, Manjula Nagalapur Gadilingappa

DOI: 10.18231/j.ijmmtd.11625.1758782202

Keywords: Antimicrobials, ESBL, MBL, Antibiotic susceptibility test, Colistin.

The limited treatment options have elevated an increased cause of concerns toward the emerging antimicrobial resistance amongst the bacterial pathogens in hospital settings, causing respiratory tract...

Concordance of Enterococcus species identification by two different identification systems VITEK2 and MALDI-TOF, compared with WGS (gold standard).

Authors: shital sangani, Anant Prabhakar Marathe, Bhavita Thakorbhai Prajapati, Asmabanu Mahammed Hanif Shaikh

DOI: 10.18231/j.ijmmtd.12016.1760520062

Keywords: Bloodstream infections,Enterococcus,MALDI-TOF,VITEK2,Whole Genome Sequencing

Abstract: Aims & Objective: This study aims to compare the performance of two commercial systems, VITEK2 and MALDI-TOF (Matrix-assisted laser desorption-ionization time-of-flight mass spectrometry), i...

Biomarkers and Gold Standard: Assessing CRP, Procalcitonin, and Blood Culture in the Diagnosis of Neonatal Septicemia

Authors: MIHIRKUMAR J BHALODIA, Nidhi Mihirkumar Bhalodia, Kuntal Devesh Patel, Dr.Jasmin Jasani

DOI: 10.18231/j.ijmmtd.11903.1761394292

Keywords: Neonatal septicemia, Staphylococcus aureus, Acute phase reactant, C-reactive protein, Procalcitonin

Background Neonatal septicemia is a leading cause of morbidity and mortality among newborns worldwide, posing a significant public health concern. (1) The incidence of neonatal sepsis ranges from 1 t...

An Unusual Case of Disseminated Hydatid Cyst of Liver, Spleen and Urinary bladder

Authors: Jigna P. Patel, Jaina A. Shah, Mansi D. Rupani

DOI: 10.18231/j.ijmmtd.11948.1759746971

Keywords: Cyst within cyst appearance, Hydatid cysts, Livestock-producing countries, Spoke in wheel appearance

Hydatid disease is a common health problem in endemic regions, particularly in livestock-producing countries. Humans acquire infestation of echinococcus by swallowing the ova accidentally. Infections...

BEYOND ALLERGENS: A PARASITIC TWIST IN ASTHMA EXACERBATION – CASE REPORT

Authors: Dr Aishwarya Alavandar, Dr.Koushik MuthuRaja Mathivanan

DOI: 10.18231/j.ijmmtd.12012.1761566473

Keywords: Strongyloidiasis, asthma, acute exacerbation, ivermectin, parasitic infection

Case Presentation: A 34-year-old female with a known history of bronchial asthma on regular inhaled therapy presented with acute worsening of respiratory symptoms. She reported progressive cough, whee...

Assessment of VITEK 2 system and MALDI-TOF MS for Identification of Lactose-Fermenting Bacteria: Comparing with Whole-Genome Sequencing - as a Gold Standard.

Authors: Bhavita Thakorbhai Prajapati, Anant Prabhakar Marathe, Asmabanu Mahammed Hanif Shaikh, shital sangani

DOI: 10.18231/j.ijmmtd.12048.1761395421

Keywords: MDR lactose fermenters, WGS, MALDI-TOF MS, VITEK 2 system, percentage of agreement

Introduction: The Vitek 2 system is used widely for ID and AST of clinical bacterial isolates. MALDI-TOF-MS was once used to study accuracy and reproducibility. Recently, WGS has been instrumental in...

Title: Genetic diversity of A.baumannii sequence types isolated from VAP patients: A retrospective study from a tertiary care hospital in Vadodara, Gujarat.

Authors: Asmabanu Mahammed Hanif Shaikh, Anant Prabhakar Marathe, Bhavita Thakorbhai Prajapati, Shital Sangani

DOI: 10.18231/j.ijmmtd.12056.1761566877

Keywords: A.baumannii , Sequence Type, Ventilator Associated Pneumonia

Introduction- A.baumannii is a Gram-negative, lactose-nonfermenting, oxidase-negative nosocomial pathogen. A.baumannii is one of the pathogens in the ESKAPE group associated with global health threat...

Estradiol-Associated Shifts in Vaginal Microbiota: Insights from Menopausal and Reproductive Women

Authors: Siti Anissa Safira, Sharvianty Arifuddin, Fatmawati Madya, Andi Alfian Zainuddin, Sriwijaya Sriwijaya, Irma Savitri

DOI: 10.18231/j.ijmmtd.12107.1759749938

Keywords: estradiol, dysbiosis, menopause, microbiota

Background and Objective: Estradiol plays a key role in maintaining vaginal microbial balance, particularly by supporting Lactobacillus dominance. Hormonal shifts during menopause may disrupt this bal...

“PREVALENCE OF MULTIDRUG RESISTANT PSEUDOMONAS AERUGINOSA FROM CLINICAL SAMPLES AT A TERTIARY CARE CENTRE CHENNAI”

Authors: Dr.Udhayakumar Selvam, Dr.Sivaharivelan Thiagarajan, Dr.Balakumar M, Dr.Asha Balaraman, Dr.Ananthi B

DOI: 10.18231/j.ijmmtd.12175.1761392754

Keywords: Pseudomonas, Multidrug resistance, Clinical samples.

Abstract Background: Pseudomonas aeruginosa is a significant opportunistic pathogen commonly associated with healthcare-associated infections. Its ability to resist multiple antibiotics through intrin...

Detection of antibiotic resistance and metallo beta lactamase among Pseudomonas aeruginosa clinical isolates

Authors: Dr.Vijayashree MBBS MD, Ganesh Perumal PerumalSamy, Dr.Banumathy MBBS MD, Dr.A.R.Preetthi MBBS MD

DOI: 10.18231/j.ijmmtd.12225.1761651771

Keywords: Key words: Modified Hodge, MBL,E-test.

Introduction: MBL generating Pseudomonas aeruginosa (MBL-PA) have a significant clinical problem that poses a significant obstacle to antimicrobial therapy. Aim: The aim of this study was to detect t...

LABORATORY APPROACHES TO DETECT VANCOMYCIN-RESISTANT AND VANCOMYCIN-VARIABLE ENTEROCOCCI: CURRENT PERSPECTIVES

Authors: SivaSakthi Srikanth, Valentina Yogamoorthi, Vinoj Gopalakrishnan, Joshy M Easow

DOI: 10.18231/j.ijmmtd.12298.1761390851

Keywords: vancomycin-resistant enterococci, vancomycin-variable enterococci, Phenotypic methods, Genotypic methods

The global spread of vancomycin-resistant enterococci (VRE), particularly Enterococcus faecium and Enterococcus faecalis, poses a substantial healthcare risk due to limited treatment options and a hig...

Improving Carbapenem Resistance Identification: A Comprehensive Evaluation of bc-CIM in Positive Blood Cultures

Authors: Spandan M D, Dr Deepashree Rajshekar, Dr Sujatha S R, Nivedita Varma, Shalini Prasanna Kumar

DOI: 10.18231/j.ijmmtd.12473.1761393248

Keywords: Keywords: Drug resistance, Blood cultures, Carbapenem inactivation method, bc-CIM.

Abstract Background: Early detection of drug resistance in blood culture positives is essential for effective clinical management. It enables timely and targeted antibiotic therapy, reduces the spread...

Helicobacter pylori: A key player in pathogenesis of Gastric Non-Hodgkin’s Lymphoma: A Case Report

Authors: trupti jansari, JAY JANSARI, VISHWA GEVARIYA, AMIT PRAVIN CHAUHAN, Shikha shah

DOI: 10.18231/j.ijmmtd.12628.1761393749

Keywords: stomach, helicobacter pylori, lymphoma, non – Hodgkin’s lymphoma, immunohistochemistry.

Primary gastric lymphoma is one of the less common gastric malignancies as compared to adenocarcinoma. Numerous bacterial and viral infections are linked to their etiology. One of the most frequent as...

Culture and Sensitivity in Breast Cancer Patients with Sepsis: A Retrospective Observational Study

Authors: Veena Boswal, Anmol Mahani, Luckshay Sharma, Vipul Nautiyal, Viney Kumar, Mansi Barthwal

DOI: 10.18231/j.ijmmtd.12678.1761892749

Keywords: Breast Cancer, Sepsis, Chemotherapy, Antibiotic Resistance, Culture Sensitivity, Multidrug Resistance

Abstract Background: Sepsis is a life-threatening complication in breast cancer patients, particularly those undergoing chemotherapy or radiotherapy. Immunosuppression, neutropenia, and mucosal damage...

Comparison of in vitro activity of cefepime-enmetazobactam and other carbapenem-sparing agents for gram negative uropathogens

Authors: Kalaivani Ramakrishnan, Arunava Kali, Sarah Korah, Thouheedha Banu S, Srirangaraj Sreenivasan

DOI: 10.18231/j.ijmmtd.12708.1760517812

Keywords: Cefepime-enmetazobactam, Carbapenem-sparing antibiotic, Extended-Spectrum β-Lactamase, Multidrug-resistance

Background: Urinary tract infections (UTIs) caused by Gram-negative bacteria are an emerging therapeutic concern due to resistance to third-generation cephalosporins associated with Extended-spectrum...

Oral lichen planus and lichenoid reactions in bronchial asthma patients: a case-control study on prevalence and clinicopathological associations

Authors: Ashwini Deshpande, Krishnan Rajkumar, Parijat Goswami, Amit Byatnal

DOI: 10.18231/j.ijmmtd.12877.1761737217

Keywords: Corticosteroid-Associated Oral Lesions, Drug-Induced Oral Lesions, Lichenoid Drug Reactions, Mucosal Immunopathology, T-Cell Mediated Immunity

Background: Chronic inflammatory oral conditions like oral lichen planus (OLP) and oral lichenoid reactions (OLR) have been associated with systemic disorders and pharmacological treatments. Bronchial...

Bacterial profile and antibiotic susceptibility pattern of uropathogens in patients attended Obstetrics and Gynecology outpatient clinic in a tertiary care hospital Assam

Authors: Partha Pratim Das, Tonushyam Sonowal, Jashbeer Singh Roy, Subhrendu Sekhar Sen, Rohan Raj Kutum

DOI: 10.18231/j.ijmmtd.13103.1761737603

Keywords: Antibiotic susceptibility testing; Multidrug resistance, Obstetrics and Gynecology clinic, Urinary tract infection;

Background: Urinary tract infection (UTI) is one of the most common bacterial infection during pregnancy that lead to significant perinatal and maternal morbidity. In hospital it is the second most co...

Challenges and perspectives in Dengue control: Are we ready to tackle the rising threat ?

Authors: Lakshmi Krishnasamy

DOI: 10.18231/j.ijmmtd.13061.1761567892

Keywords: Dengue,challenges,diagnosis,treatment,vector control,research

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Molecular Characterization of Pseudomonas aeruginosa Isolates from Chronic Kidney Disease Patients

Authors: Haider Sabah Abdulhussein, Sarah A. Al-khafaji, Moslim Mohsin Khalaf

DOI: 10.18231/j.ijmmtd.13326.1761984669

Keywords: Pseudomonas aeruginosa, chronic kidney disease, oprL gene, toxA gene, exoS gene, molecular characterization, virulence factors.

Pseudomonas aeruginosa is an important opportunistic pathogen that causes sufficient risk of chronic kidney disease (CKD) in patients due to their compromised condition. P. aeruginosa The molecular is...